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1/16 finales
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| MA | 11/10/2010 | 19:00 | ZVK Wezent 06 - Blue Sky | - |  |
| MA | 11/10/2010 | 20:00 | ZVV MMM - Team Boys | - | |
| MA | 11/10/2010 | 21:00 | VZVK - The Red Sharks | - | |
| MA | 11/10/2010 | 22:00 | Rema Sport - ZVK Parais | - | |
| WO | 13/10/2010 | 19:00 | Sturm und Drang - Reynaert | - | |
| WO | 13/10/2010 | 20:00 | Atletica 92 - BaLiMi | - | |
| WO | 13/10/2010 | 21:00 | The Spartans - Kwekerij | - | |
| VR | 15/10/2010 | 21:00 | De Keuj - Provan | - | |
| VR | 15/10/2010 | 22:00 | ZVK Comedie - Plekkerboys | - | |
| ZO | 17/10/2010 | 20:00 | Eendracht Achteruit - ZVK Limburgia | - | |
| ZO | 17/10/2010 | 21:00 | Komilfoo - Cosmos | - | | |
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